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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.11, p.816–820,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.11, p.816–820,2021
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Bratislava Medical Journal Vol.122, No.11, p.816–820,2021 |
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| Title: Effects of serum vitamin D level on ventricular repolarization in children and adolescents | ||
| Author: M. Bekdas, M. Inanir, Z. Ilhan, E. Ildes | ||
| Abstract: OBJECTIVES: Low levels of vitamin D are known to increase cardiovascular mortality due to different risks. We aimed to examine whether low vitamin D levels in children and adolescents cause ventricular repolarization changes. METHODS: Sixtyseven healthy cases aged between 3.5 and 17 years were included. According to levels of vitamin D, cases were grouped as sufficient (n=44), insufficient (n=13) and deficiency (n=10). Ventricular repolarization parameters were measured manually. RESULTS: Levels of vitamin D were different for cases with insufficiency and deficiency compared to sufficiency ones (102±54.9 vs 24.4±7 ng/ml, p<0.001 and 102±54.9 vs 16.6±8.3 ng/ml, respectively, p<0.001). In the insufficient group the following parameters were different from sufficient group: QTmean (357.8±25.3 vs 332±29.9 ms, p=0.012), JTc (310.8±20.2 vs 331.6±21 ms, p=0.005) and Tpe/QT (0.2±0.02 vs 0.22±0.02, p=0.02). It was found that the level of serum vitamin D correlated with JTc (r=–0.37, p=0.002), Tp-e (r=–0.29, p=0.015) and Tp-e/QT (r=–0.24, p=0.047). In the linear regression analysis, it was found that dropping level of vitamin D below normal was an independent risk factor for prolonged duration of JTc (p=0.015). CONCLUSIONS: Decline in vitamin D levels causes ventricular repolarization anomaly. As the decrease in vitamin D levels deepens, repolarization times become longer. These results could indicate that decrease in vitamin D levels can increase sensitivity to ventricular arrhythmias (Tab. 3, Ref. 45). Text in PDF www.elis.sk |
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| Keywords: adolescent, arrhythmia, child, vitamin D, ventricular repolarization | ||
| Published online: 21-Oct-2021 | ||
| Year: 2021, Volume: 122, Issue: 11 | Page From: 816, Page To: 820 | |
| doi:10.4149/BLL_2021_130 |
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