Home Neoplasma 2021 Neoplasma Vol.68, No.6, p.1310–1319, 2021

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.68, No.6, p.1310–1319, 2021

Title: Expression and prognostic significance of the DNA damage response pathway and autophagy markers in gastric cancer
Author: Xin-Bo Xu, Nians-Huang Li, Huan Wang, Yi Hu, Xi-Dong Wu, Jun-Bo Hong, Nong-Hua Lu, Chuan Xie

Abstract: Gastric cancer (GC) is a leading cause of mortality and morbidity worldwide. We assessed the expression patterns of DNA damage response (DDR)-related markers, including ATM, CHK2, p-p53 (S15), Rad51, and BRCA2 and autophagy-related proteins including p62 and Beclin-1 in 153 GC specimens using immunohistochemistry staining. GC tissues showed lower levels of ATM, CHK2, p-p53, BRCA2, and higher levels of Rad51 compared to adjacent normal tissues. The autophagy-related protein p62 was upregulated, whereas Beclin-1 was downregulated in human GC groups. Additionally, different statuses of DDR pathways and autophagy characterized by protein expression were associated with overall survival. Our results indicated that the impairment of DNA damage and autophagy may be implicated in gastric cancer progression and its clinical prognosis.

Keywords: DNA damage response; autophagy; gastric carcinoma; immunohistochemistry
Published online: 25-Oct-2021
Year: 2021, Volume: 68, Issue: 6 Page From: 1310, Page To: 1319

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