Home FOR AUTHORS Neoplasma Ahead of print Neoplasma Vol.69, No.1, p.183–192, 2022

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Neoplasma Vol.69, No.1, p.183–192, 2022

Title: High GNG13 expression is associated with poor survival in epithelial ovarian cancer and breast cancer
Author: Yuanlin Liu, Shuting Gu, Tong Wu, Yunzhao Xu, Qi Meng, Zongyu Guan, Xiaojing Zhang, Xiaoli Sun, Yi Shen, Haowen Fan, Changjiang Gu, Jinlian Feng

Abstract: Recently, change in the GNG13 expression has been shown to result in multiple congenital malformations and sexual reversal, and it was also found in the brain. The aim of this study was to measure the expression levels in epithelial ovarian cancer (EOC) and breast cancer (BC) and assess their value as a potential prognostic marker.
The correlation of GNG13 protein expression was detected by immunohistochemistry (IHC) in 119 EOC and 125 BC tissues. Assessment of the associations between GNG13 levels and various clinicopathological features was identified, the relationship between GNG13 and prognosis in BC and EOC patients was analyzed using online resources of Oncomine and Kaplan-Meier plotter. Protein expression levels of GNG13 were both significantly lower in BC and EOC compared with normal tissues (p umor growth in EOC and BC.

Keywords: guanine nucleotide binding protein 13; breast cancer; epithelial ovarian cancer; prognosis; poor survival
Published online: 04-Nov-2021
Year: 2022, Volume: 69, Issue: 1 Page From: 183, Page To: 192
doi:10.4149/neo_2021_210603N745


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