Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.68, No.6, p.1132–1138, 2021 |
||
Title: Research progress on the treatment of advanced prostate cancer with Olaparib | ||
Author: Yi-Xin Su, Cheng-Feng Yu, Peng Xue, Lin-Lu Li, Kun-Min Xiao, Xue-Lei Chu, Shi-Jie Zhu | ||
Abstract: Prostate cancer (PCa) is one of the most common malignancies in men worldwide, and metastatic castrate-resistant prostate cancer (mCRPC) has shown a poor prognosis. Although chemotherapy and androgen deprivation therapy (ADT) have improved clinical outcomes, the median survival (MS) of patients with mCRPC is still less than 2 years. With the development of poly adenosine diphosphate-ribose polymerase inhibitor (PARPi), the treatment strategy for patients with mCRPC has markedly evolved. Olaparib, a type of PARPi that can selectively induce synthetic lethality in cancer cells with homologous recombination (HR) deficiencies, was the first type of PARPi approved for treating patients with mCRPC harboring mutations in HR repair (HRR) genes. This review discusses and summarizes the latest progress on therapeutic mechanisms, monotherapy, combination therapy, and adverse events of Olaparib. |
||
Keywords: Olaparib; advanced prostate cancer; research progress; homologous recombination repair; synthetic lethality | ||
Published online: 15-Nov-2021 | ||
Year: 2021, Volume: 68, Issue: 6 | Page From: 1132, Page To: 1138 | |
doi:10.4149/neo_2021_210627N856 |
||
|
download file |
|