Home FOR AUTHORS Neoplasma Ahead of print Neoplasma Vol.69, No.1, p.28–35, 2022

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Neoplasma Vol.69, No.1, p.28–35, 2022

Title: Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs
Author: Lenka Krsková, Igor Odintsov, Ondřej Fabián, Petra Hroudová, Marcela Mrhalová

Abstract: We present a retrospective study of 65 cases of solitary fibrous tumors (SFTs) of several localizations including the most common site of origin in the pleura and lungs. SFTs are mesenchymal fibroblastic tumors with an unpredictable biological potential raging from benign to malignant. We investigated morphologic characteristics, proliferation activity evaluated by immunohistochemical expression of Ki-67 antigen, and the existence of NAB2-STAT6 fusion gene together with Ki-67, TPX2, and TERT mRNA expression levels. The aim was to define relationships between proliferation activity and biological potential and progression of the disease. We measured Ki-67, TPX2, and TERT mRNA levels using quantitative real-time reverse transcription PCR (RQ-RT-PCR). We observed a significant association between increased Ki-67 and TERT mRNA levels and the SFTs with malignant potential. Also, we investigated the effect of TERT promoter mutation on telomerase activation and patient outcome in our SFT cohort. We verified that TERT promoter mutation was frequent (36.6%) and present in a majority of malignant SFTs and SFTs with uncertain biological behavior. TERT promoter mutation alone predicted the disease recurrence.

Keywords: solitary fibrous tumors (SFTs); NAB2-STAT6; proliferation markers; biological behavior; prognosis, TERT
Published online: 24-Nov-2021
Year: 2022, Volume: 69, Issue: 1 Page From: 28, Page To: 35
doi:10.4149/neo_2021_210511N642


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