Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.6, p.443–462, 2021

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.40, No.6, p.443–462, 2021

Title: Pathophysiology of the choroid plexus in brain diseases
Author: Sandra Mihaljevic, Alena Michalicova, Mangesh Bhide, Andrej Kovac
Abstract: The choroid plexus, located in the ventricular system of the central nervous system (CNS), obtains numerous roles critical for the proper development and operating of the CNS. The functions range from the best-known ones of the barrier and cerebrospinal fluid (CSF) producer, through participation in immune answer, ‘nourishment, detoxification and reparation of the rest of the CNS. Increase number of studies point out the association between choroid plexus dysfunction, characterized by alterations in secretory, transport and barrier capabilities, and the broad spectrum of clinical conditions, as well as physiological aging. We present a brief overview of pathological states known or speculated to be connected to choroid plexus dysfunction, ranging from neurodevelopmental, to autoimmune and neurodegenerative diseases. We also cover the topic of choroid plexus tumors, as well explained involvement of the choroid plexus in pathogen invasion of the CNS, also referring to the currently actual SARS-CoV-2 infection. Finally, we have also touched conducted studies on the choroid plexus regenerative potential. With the information provided in the review we want to point out the importance and call for further research on the role of the choroid plexus in the sustainability of central nervous system health.
Keywords: Aβ, amyloid beta; AD, Alzheimer’s disease; BBB, blood-brain barrier; BCSFB, blood-cerebrospinal fluid barrier; CP, choroid plexus; CPECs, choroid plexus epithelial cells; CPe, choroid plexus epithelium; CSF, cerebrospinal fluid; ICP, intracranial pressure; LPS, lipopolysaccharide; MMP, matrix metalloproteinase; NO, nitric oxide; TJs, tight junctions.
Published online: 30-Nov-2021
Year: 2021, Volume: 40, Issue: 6 Page From: 443, Page To: 462
doi:10.4149/gpb_2021032


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