Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.6, p.463–478, 2021

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.40, No.6, p.463–478, 2021

Title: The engagement of microglia in tau-targeted immunotherapy in Alzheimer’s disease
Author: Denisa Palova, Natalia Turic Csokova, Karina Markova, Eva Kontsekova, Branislav Kovacech, Monika Zilkova

Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative disease characterized by progressive memory decline, histopathological lesions such as amyloid β plaques and neurofibrillary tangles, and neuroinflammation driven by glial cells. Microglia, the innate immune cells of the brain, dynamically survey their environment for signs of infection and cell damage. Although our understanding of microglia and their modes of activation has expanded in recent years, their role in AD is still not completely understood. Broad range of microglia phenotypes, from neuroinflammatory to neuroprotective, found in neurodegenerative diseases make their role difficult to discern. In this review, we summarize activities of microglia in healthy and AD brains and their possible role during immunotherapy targeted against pathological tau proteins.

Keywords: Alzheimer’s disease — Microglia — Neuroinflammation — Tau immunotherapy
Published online: 30-Nov-2021
Year: 2021, Volume: 40, Issue: 6 Page From: 463, Page To: 478

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