Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.6, p.479–493, 2021

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.40, No.6, p.479–493, 2021

Title: The structure of the unstructured: mosaic of tau protein linear motifs obtained by high-resolution techniques and molecular simulation
Author: Ondrej Cehlar, Olga Bagarova, Lenka Hornakova, Rostislav Skrabana

Abstract: Intrinsically disordered proteins are flexible molecules with important physiological functions. Their mode of action often involves short segments, called linear motifs, which may exhibit distinct structural propensities. Tau is intrinsically disordered, microtubule-associated protein involved in the pathogenesis of various tauopathies. In this review we analyze the collection of 3D structures of tau local linear motifs gained from the deposited structures of tau complexes with various binding partners as well as of tau-tau complexes; determined by X-ray and electron crystallography, single-particle electron microscopy, NMR spectroscopy and molecular dynamics simulations. Insights into the partially stabilized conformations of tau linear motifs are valuable for understanding the physiological and pathological processes involving tau protein.

Keywords: Tau protein — Conformation — Linear motif — Antibody — X-ray crystallography
Published online: 30-Nov-2021
Year: 2021, Volume: 40, Issue: 6 Page From: 479, Page To: 493

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