Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.6, p.551–559, 2021

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.40, No.6, p.551–559, 2021

Title: Impact of mesenchymal stem cells derived conditioned media on neural progenitor cells
Author: Filip Humenik, Sonja Jego, Lubica Hornakova, Marcela Maloveska, Alexandra Valencakova-Agyagosova, Zuzana Vikartovska, Dagmar Mudronova, Nikola Hudakova, Monika Zilkova, Milan Cizek, Dasa Cizkova
Abstract: Neurodegenerative diseases are common problem for companion animals. Due to the limited ability of injured axons to regenerate, innovative therapies combined with rehabilitation have been applied and evaluated. Among them, stem cells and their conditioned media implantation, which can ameliorate damaged tissue has been suggested as a promising treatment strategy. The main goal of our study was to characterize mesenchymal stem cells (MSC) derived from canine adipose tissue (AT-MSC) and umbilical cord (UC-MSC) and analyse effect of their conditioned media (CM) on neurite outgrowth of neural progenitor cells isolated from the brain cortex of neonatal rats. MSC from both sources showed high osteogenic and chondrogenic potential and expression of CD90 and CD29. Furthermore, both UC-MSCCM and AT-MSCCM stimulated neurite growth. Interestingly, this effect was more pronounced with UC-MSCCM when compared to AT-MSCCM in vitro, which may be related to the different content of neurotrophic factors included in the CM.
Keywords: Neural progenitor cells — Mesenchymal stem cells — Umbilical cord — Adipose tissue neurite growth
Published online: 30-Nov-2021
Year: 2021, Volume: 40, Issue: 6 Page From: 551, Page To: 559
doi:10.4149/gpb_2021026


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