Home General Physiology and Biophysics 2021 General Physiology and Biophysics Vol.40, No.6, p.577–584, 2021

Journal info


Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.40, No.6, p.577–584, 2021

Title: Hypertension does not alter disturbances in leptin signalling observed in experimental model of tauopathy
Author: Martin Cente, Tomas Smolek, Stefan Zorad, Lubica Fialova, Natalia Paulenka Ivanovova, Katarina Krskova, Lucia Balazova, Rostislav Skrabana, Peter Filipcik
Abstract: Neurodegeneration is associated with hypertension and disturbance in fat metabolism. The complex interaction of neurodegenerative processes with both metabolic changes and blood pressure is still not fully elucidated. Here we demonstrate that the experimentally induced tauopathy in hypertensive transgenic animals causes significant downregulation of plasma leptin (53% of control), reduction of body weight by 11%, a 1.2-fold drop of adiposity index, and decrease in HDL cholesterol level, while the fasting glucose and insulin concentration remain unchanged. Despite of these alterations we found the leptin projection circuit including the arcuate nucleus, paraventricular nucleus in hypothalamus, and nucleus tractus solitarius in the brainstem not affected by neurofibrillary pathology. Furthermore, hypertension does not alter disturbances in leptin signalling. The presented data provide further insight into neurodegeneration-induced metabolic alterations relevant for human tauopathies.
Keywords: Neurodegeneration — Tau — Leptin — Hypertension — Transgenic rat
Published online: 30-Nov-2021
Year: 2021, Volume: 40, Issue: 6 Page From: 577, Page To: 584
doi:10.4149/gpb_2021037


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.