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Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.12, p.853–860,2021
Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.12, p.853–860,2021
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Bratislava Medical Journal Vol.122, No.12, p.853–860,2021 |
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| Title: Analysis of HLA-G 5′URR regulatory polymorphisms in Slovak women with pre-eclampsia | ||
| Author: V. Durmanova, J. Drobny, J. Dlhopolcek, M. Bucova | ||
| Abstract: OBJECTIVES: The objective of this study was to identify the impact of the selected HLA-G gene polymorphisms in the 5′URR region on the risk to develop pre-eclampsia. BACKGROUND: Pre-eclampsia (PE) is a serious multisystem disorder that affects women during pregnancy. Despite many research studies, the pathology of PE is not fully understood. Human leukocyte antigen G (HLA-G) belongs to the molecules that induce immune tolerance at the fetal-maternal interface. HLA-G expression was found to be impaired in the women suffering from PE suggesting its involvement in the development of PE. METHODS: 116 women with pre-eclampsia and 130 women with normotensive pregnancy were included in the study. The 16 gene polymorphisms in the HLA-G 5′URR region (promoter) affecting HLA-G expression were typed by direct sequencing. RESULTS: The -201AA genotypes in recessive model were significantly more frequent in women with pre-eclampsia than in the controls (p = 0.047). Furthermore, the analysis of HLA-G 5′URR variants with clinical findings of PE showed a significant association of the -533delA-/+ genotype with a higher mean level of diastolic blood pressure (p = 0.02). CONCLUSION: Our results suggest a genetic association of selected HLA-G 5′URR variants with a risk of developing pre-eclampsia and possible contribution of HLA-G to disease pathology (Tab. 4, Ref. 51). |
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| Keywords: HLA-G, pre-eclampsia, gene polymorphism, sequencing, diagnostics | ||
| Published online: 14-Dec-2021 | ||
| Year: 2021, Volume: 122, Issue: 12 | Page From: 853, Page To: 860 | |
| doi:10.4149/BLL_2021_138 |
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