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CONTACT Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.12, p.861–865, 2021
CONTACT Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.12, p.861–865, 2021
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Bratislava Medical Journal Vol.122, No.12, p.861–865, 2021 |
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| Title: COVID-19 symptom duration predicts immunoglobulin G seropositivity | ||
| Author: L. Stepanek, M. Nakladalova, L. Stepanek, M. Janosikova, A. Borikova, H. Vildova | ||
| Abstract: OBJECTIVES: The study focused on the relationship between routine clinical characteristics and anti-SARS-CoV-2 specific antibodies in a pilot sample of healthcare workers (HCWs) having suffered COVID-19. The aim was to investigate the existence of readily available predictors of antibodies against COVID-19. METHODS: As part of the recognition of COVID-19 as an occupational disease in 152 HCWs with the mean age of 43.2 years, personal, anthropometric and anamnestic data related to the disease as well as anti-spike immunoglobulin (Ig) levels were obtained. Through descriptive statistics, correlation and regression analyses, relationships of all variables and Ig levels, especially seropositivity of IgG, were investigated. RESULTS: The mean interval between the symptom onset and the determination of antibodies was 58 days. IgG seropositivity and IgM seropositivity were noted in 82 % and 49 % of HCWs, respectively. Symptom duration was the only statistically significant predictor of IgG seropositivity. With each day of symptom duration, the probability of IgG seropositivity increased from 1.078 to 1.092 times (p < 0.05). If symptoms lasted longer than 17 days, a majority (almost 80 %) of the subjects demonstrated seropositivity in the following months. CONCLUSION: The presence of IgG immunity may be assumed from symptom duration. Such easy recognizing of seropositive patients may be a useful tool, e.g. in vaccination strategies (Tab. 3, Fig. 1, Ref. 28). |
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| Keywords: SARS-CoV-2, COVID-19, seropositivity, antibody, immunoglobulin, predictor | ||
| Published online: 14-Dec-2021 | ||
| Year: 2021, Volume: 122, Issue: 12 | Page From: 861, Page To: 865 | |
| doi:10.4149/BLL_2021_139 |
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