Home Bratislava Medical Journal 2021 Bratislava Medical Journal Vol.122, No.12, p.912–917, 2021

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2

 

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Bratislava Medical Journal Vol.122, No.12, p.912–917, 2021

Title: Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?
Author: M .Y. Gunal, S. Ayla, B. Caglayan, M. C. Beker, N. Bedri, I. Aslan, E. M. Ozdemir, E. Kilic, E. Yesilada

Abstract: OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat.
BACKGROUND: In the event of any damage, the damaged tissue undergoes a process of regenerating itself, which is called wound healing.
METHODS: Centella asiatica extract (CAE) was used as the reference molecule in the study. The wound healing process was tested by using the excisional and incisional wound model. On the 12th day of the study, maximum stress, stress, % of elongation values were evaluated in the incisional wound. Also; histological parameters and macroscopic photographic analyses were evaluated in the excisional wound.
RESULTS: In the photo evaluations, the improvement was more prominent in both CAE and CEPE groups than in the control group. Histological evaluation showed that CEPE group had significant wound healing activity compared to the control and CAE groups. Axial tensile-elongation experiments in incisional wound tissue show that there was no significant difference between CAE and CEPE groups.
CONCLUSION: Liposomal formulations of C.edulis extract were found to have positive effects on the healing process, both on excisional and incisional wound tissues (Tab. 2, Fig. 3, Ref. 30).

Keywords: Carpobrotus edulis, liposome, incisional wound, excisional wound, axial tensile-elongation tests
Published online: 14-Dec-2021
Year: 2021, Volume: 122, Issue: 12 Page From: 912, Page To: 917
doi:10.4149/BLL_2021_147


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