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Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.1, p 9–15, 2022
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.1, p 9–15, 2022
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Bratislava Medical Journal Vol.123, No.1, p 9–15, 2022 |
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| Title: Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19 | ||
| Author: Z. Sumbalova, J. Kucharska, P. Palacka, Z. Rausova, P. H. Langsjoen, A. M. Langsjoen, A. Gvozdjakova | ||
| Abstract: BACKGROUND: After an acute treatment for coronavirus disease (COVID-19), some symptoms may persist for several weeks, for example: fatigue, headaches, muscle and joint pain, cough, loss of taste and smell, sleep and memory disturbances, depression. Many viruses manipulate mitochondrial function, but the exact mechanisms of SARS-CoV-2 virus effect remain unclear. We tested the hypothesis that SARS-CoV-2 virus may affect mitochondrial energy production and endogenous biosynthesis of coenzyme Q10 (CoQ10). METHODS: Ten patients after COVID-19 and 15 healthy individuals were included in the study. Platelets isolated from peripheral blood were used as an accessible source of mitochondria. High-resolution respirometry for the evaluation of platelets mitochondrial function, and HPLC method for CoQ10 determination were used. Oxidative stress was evaluated by TBARS concentration in plasma. RESULTS: Platelet mitochondrial respiratory chain function, oxidative phosphorylation and endogenous CoQ10 level were reduced in the patients after COVID-19. CONCLUSION: We assume that a reduced concentration of endogenous CoQ10 may partially block electron transfer in the respiratory chain resulting in a reduced adenosine triphosphate (ATP) production in the patients after COVID-19. Targeted mitochondrial therapy with CoQ10 supplementation and spa rehabilitation may improve mitochondrial health and accelerate the recovery of the patients after COVID-19. Platelet mitochondrial function and CoQ10 content may be useful mitochondrial health biomarkers after SARS-CoV-2 infection (Tab. 3, Fig. 3, Ref. 46). |
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| Keywords: SARS-CoV-2, platelet, mitochondria, OXPHOS, coenzyme Q10, oxidative stress | ||
| Published online: 30-Dec-2021 | ||
| Year: 2022, Volume: 123, Issue: 1 | Page From: 9, Page To: 15 | |
| doi:10.4149/BLL_2022_002 |
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