Home Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.2, p.92–99, 2022

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.123, No.2, p.92–99, 2022

Title: An assessment of the relation between vitamin D levels and electroencephalogram (EEG) changes in migraine patients
Author: M. Canpolat, A. Topcu, F. Kardas, F. Ipekten, H. Per, H. Gumus, A. Ozturk, H. Acer, G. D. Kaya Ozcora, M. Kendirci, S. Kumandas

Abstract: BACKGROUND: The present study evaluated vitamin D therapy in migraine patients with vitamin D deficiency and EEG abnormality.
METHODS: 140 patients were divided into four groups: Group A; normal vitamin D and EEG, Group B; low vitamin D and normal EEG, Group C; normal vitamin D and pathological EEG, and Group D; low vitamin D and pathological EEG. Patients with low vitamin D received vitamin D therapy.
RESULTS: Paediatric Migraine Disability Assessment Scale (PedMIDAS) scores and median attack frequencies time-dependent changes in the patients receiving vitamin D therapy in Group B were significant (p ˂ 0.05), but not in the untreated patients in the Group A (p ˃ 0.05). Interictal EEG was pathological in 41 (29.3 %) patients.
The main EEG findings were focal/hemispheric spike/sharp wave activity at 9.3 %, bilateral/generalized spike/sharp wave activity at 8.6 %, focal slowing at 5.8 %, and bilateral slow-wave activity/background rhythm irregularity at 3.6 %. Changes in EEG findings in between the groups C and D were not significant (p ˃ 0.05).
There was no significant association between vitamin D levels ˂ 20 or ≥ 20 ng/mL and EEG findings in Group D (p ˃ 0.05).
CONCLUSION: Vitamin D therapy positively affects attack frequency and PedMIDAS scores in migraine patients with vitamin D deficiency/insufficiency. No association was determined between EEG findings and vitamin D levels or therapy (Tab. 6, Ref. 35).

Keywords: vitamin D, migraine, electroencephalogram
Published online: 23-Jan-2022
Year: 2022, Volume: 123, Issue: 2 Page From: 92, Page To: 99

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