Home HOME Neoplasma 2022 Neoplasma Vol.69, No.2, p.464–473, 2022

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Neoplasma Vol.69, No.2, p.464–473, 2022

Title: Exploring the prognosis of neuroblastoma in adolescents and adults: a case series and literature review
Author: Qian-Ya Jin, Shi-Bei Du, Xiao-Jun Yuan

Abstract: Neuroblastoma (NB) is one of the most common extracranial malignant solid tumors in childhood, and over 90% of NBs are diagnosed in children under the age of 10 years old. For patients between 14 and 18 years old or older than 18 years, due to the rarity of NB, few studies have been performed in this population. Defined "adolescent cases" as individuals in 14-18 years old and "adult cases" as older than 18 years old, we reported five NB cases of adolescents and adults in our hospital. 137 cases presented a review of published literature on this topic. Clinicopathological factors and treatment modalities used of the 142 patients were assessed for their prognostic value. Better outcomes were found in adolescent patients rather than adult patients (p = 0.012). Patients diagnosed with neuroblastoma or ganglioneuroblastoma (nodular type) (p = 0.006) and with distant metastasis (p nt and adult NB patients is needed. The anti-GD2 immunotherapy may be an effective approach for treatment.

Keywords: neuroblastoma; adolescent and adult; outcome; heterogeneity; treatment
Published online: 24-Jan-2022
Year: 2022, Volume: 69, Issue: 2 Page From: 464, Page To: 473
doi:10.4149/neo_2021_210325N399
Price: 21.00 €






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