Home HOME General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.1, p. 31–42, 2022

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ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.41, No.1, p. 31–42, 2022

Title: Roles of NOD1/Rip2 signal pathway in carotid artery remodelling in spontaneous hypertensive rats
Author: Jingsi Zhang, Bingqian Fang, Lingmin Sun, Xiuzhen Zhang, Jinli Liu, Yun Yang, Wenhua Zhang, Xiuli Wang, Yanchun Ding
Abstract: Nucleotide-binding and oligomerization domain (NOD) receptor is a member of inherent immunity recognition receptor family. We investigated the NOD1/Rip2 signalling pathway on carotid arterial remodelling in spontaneously hypertensive rats (SHRs). SHRs were treated with NOD1 agonist (iE-DAP), inhibitor (ML130), or normal saline. We determined the NOD1 and Rip2 expression in carotid artery tissues, serum tumour necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1). The carotid artery remodelling in 16-week SHRs was higher than that of 8-week SHRs and 16-week Wistar-Kyoto (WKY) rats. Expression of NOD1, Rip2, MCP-1 and TNF-α in 16-week SHRs was higher than that of 8-week SHRs and 16-week WKY rats. Blood pressure in iE-DAP-treated SHRs was higher than SHR-C group (no treatment), together with MCP-1, TNF-α, NOD1 and Rip2 expression, as well as carotid artery remodelling. In ML130-treated group, these aspects were completely the opposite. Taken together, inhibition of NOD1/Rip2 signalling pathway could delay the vascular remodelling process.
Keywords: Hypertension — Carotid artery remodelling — NOD1/Rip2 signal pathway — Inflammation — Blood pressure
Published online: 14-Feb-2022
Year: 2022, Volume: 41, Issue: 1 Page From: 31, Page To: 42
doi:10.4149/gpb_2021042


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