Home HOME General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.1, p. 53–61, 2022

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.41, No.1, p. 53–61, 2022

Title: Resveratrol improves ovarian function in aged rat by inhibiting oxidative stress and activating the Sirt1
Author: Haifeng Wu, Jianchang Xue, Hongqin Di, Cuiting Lv, Yali Hao, Zhaoyan Nie
Abstract: Oxidative stress is a leading driver of ovarian aging. Silent mating-type information regulation 2 homolog-1 (Sirt1) plays an role in ovarian function. Resveratrol has numerous effects, including anti-oxidant and Sirt1 activator. The aim of the study was to investigate the effect of resveratrol on aging-induced ovarian change in rats. The female Sprague Dawley rats were randomly divided into three groups: young control (Con), Aged+Res (20 mg/kg/day resveratrol for 45 days), and Aged. Anti-Müllerian hormone (AMH) was detected by ELISA assay. Malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were detected by conventional method.
The ovarian structure and follicles were observed by hematoxylin staining, the caspase-3 and Sirt1 were detected by immunohistochemistry and Western blotting. The AMH in the Aged+Res group was elevated, compared to that in Aged group (p in the Aged+Res group (p cate that resveratrol can delay ovarian aging, probably by reducing oxidative damage and increasing Sirt1.
Keywords: Resveratrol — Aging — Ovary — Oxidative stress — Sirt1
Published online: 14-Feb-2022
Year: 2022, Volume: 41, Issue: 1 Page From: 53, Page To: 61
doi:10.4149/gpb_2021040


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