Home 
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.3, p.178–184, 2022
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.3, p.178–184, 2022
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.123, No.3, p.178–184, 2022 |
||
| Title: Lipid kinetics in patients with non-fermenting Gram-negative bacterial ventilator-associated pneumonia | ||
| Author: Omur ILBAN, Aysegul ILBAN | ||
| Abstract: OBJECTIVES: In non-fermenting Gram-negative bacilli (NFGNB) infections, the interaction between the immune system of the host and the bacteria plays a more important role in determining the pathogenesis than the virulence factors of bacteria per se. We aimed to evaluate the sequential changes in the inflammatory response, including the lipid profile, antimicrobial susceptibility, and outcomes in NFGNB ventilator-associated pneumonia (VAP). METHODS: A total of 81 patients who developed NFGNB VAP were divided into two groups, namely multi-drug resistant (MDR) (n=51) and non-MDR (n=30) groups. RESULTS: When compared with the control group, the cholesterol levels of VAP patients decreased, while the levels of C-reactive protein and procalcitonin (PCT) levels significantly increased (p<0.05). The best sensitivity (93 %) corresponds to PCT levels on day 4, and the best specificity (89 %) corresponds to the levels of high-density lipoprotein (HDL) on day 4, which makes the latter parameters suitable candidates for predicting the 30-day mortality. The impact of resistant NFGNB isolates on early and late mortality rates was similar. CONCLUSION: In NFGNB VAP patients, the change relative to antimicrobial resistance was not appreciated in either the systemic inflammatory response or disease severity. MDR NFGNB isolates were not associated with greater mortality in VAP patients. The decrease in serum HDL and increase in PCT on day 4 indicated a poor prognosis (Tab. 5, Fig. 2, Ref. 30). |
||
| Keywords: Gram-negative bacteria, inflammatory response, lipid metabolism, multiple drug resistance, ventilator-associated pneumonia | ||
| Published online: 15-Feb-2022 | ||
| Year: 2022, Volume: 123, Issue: 3 | Page From: 178, Page To: 184 | |
| doi:10.4149/BLL_2022_029 |
||
|
|
 download file |
|