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Neoplasma Vol.69, No.3, p.630–639, 2022 |
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Title: Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ | ||
Author: Hyang Joo Ryu, Ja Seung Koo | ||
Abstract: Normal 0 21 false false false EN-US ZH-CN AR-SA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normálna tabuľka"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:8.0pt; mso-para-margin-left:0cm; line-height:107%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-ansi-language:EN-US; mso-fareast-language:EN-US;} Glucose and glutamine metabolism is involved in important tumor mechanisms. Metabolism-related protein expression has been previously reported to predict tumor prognosis. We aimed to investigate glucose and glutamine metabolism-related protein expression and its implication in breast ductal carcinoma in situ (DCIS). A tissue microarray was prepared for 205 DCIS cases. Glucose and glutamine metabolism-related proteins were immunostained. Based on the results of estrogen receptor, progesterone receptor, human epidermal growth factor receptor (HER)-2, and Ki-67, DCIS was classified into the luminal type, HER-2 type, and triple-negative breast cancer (TNBC). DCIS stroma was classified into non-inflammatory and inflammatory types per stromal histology. DCIS (n = 205) were classified into luminal type (n = 112), HER-2 type (n = 81), and TNBC (n = 12). Hexokinase II (p = 0.044), GLS (p = 0.003), and SLC7A5 (p <0.001) expression rates were the highest in TNBC. Inflammatory type stroma showed higher SLC7A5 (p <0.001) and SLC7A11 (p=0.008) expression rates than non-inflammatory type stroma. In summary, DCIS demonstrated differential expression of metabolism-related proteins according to the molecular subtype and stromal features. TNBC showed the highest glucose and glutamine metabolism-related protein expression, and inflammatory type stroma showed higher glutamine metabolism-related protein expression than non-inflammatory type stroma. |
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Keywords: breast; ductal carcinoma in situ; metabolism; glucose; glutamine | ||
Published online: 10-Mar-2022 | ||
Year: 2022, Volume: 69, Issue: 3 | Page From: 630, Page To: 639 | |
doi:10.4149/neo_2022_220103N3 |
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