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Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022
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Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022 |
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| Title: Acute phase of COVID-19 is associated with elevated plasmablasts in the blood | ||
| Author: Ondrej BERAN, Katerina MATUSKOVA, Zofia BARTOVSKA, Oldrich BARTOS, Michal HOLUB | ||
| Abstract: OBJECTIVES: The study was aimed at the characterization of humoral immunity in acute SARS-CoV-2 infection. BACKGROUND: Humoral immunity plays a central role in the protection from infection due to SARS-CoV-2, causative agent of coronavirus diseases 2019 (COVID-19). PATIENTS AND METHODS: In 24 adult patients hospitalized with COVID-19, the functional subsets of circulating B-lymphocytes and SARS-CoV-2 specific IgA and IgG antibodies were analyzed using a flow cytometry and immunoassays, respectively. RESULTS: Circulating plasmablasts and memory B-lymphocytes were significantly elevated and regulatory B-lymphocytes significantly decreased in the patients in comparison with 11 age- and sex-matched SARS-CoV-2 seronegative healthy adults. Next, circulating plasmablasts correlated negatively with the levels of SARS-CoV-2 specific IgG antibodies, which were detectable in 9 out of 15 tested patients. In addition, SARS-CoV-2 specific IgA antibodies were detectable in 13 of 15 tested patients and did not demonstrate correlation with any B-lymphocyte subset. CONCLUSION: Severe course of COVID-19 is associated with significant changes of phenotypes of circulating B-lymphocytes and elevated circulating plasmablasts correlate with decreased SARS-CoV-2-specific IgG antibodies (Tab. 2, Fig. 3, Ref. 14). |
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| Keywords: COVID-19, B-lymphocytes, immunoglobulin A, immunoglobulin G | ||
| Published online: 16-Mar-2022 | ||
| Year: 2022, Volume: 123, Issue: 4 | Page From: 244, Page To: 247 | |
| doi:10.4149/BLL_2022_039 |
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