Home 
FOR AUTHORS Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022
FOR AUTHORS Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.123, No.4, p.244–247, 2022 |
||
| Title: Acute phase of COVID-19 is associated with elevated plasmablasts in the blood | ||
| Author: Ondrej BERAN, Katerina MATUSKOVA, Zofia BARTOVSKA, Oldrich BARTOS, Michal HOLUB | ||
| Abstract: OBJECTIVES: The study was aimed at the characterization of humoral immunity in acute SARS-CoV-2 infection. BACKGROUND: Humoral immunity plays a central role in the protection from infection due to SARS-CoV-2, causative agent of coronavirus diseases 2019 (COVID-19). PATIENTS AND METHODS: In 24 adult patients hospitalized with COVID-19, the functional subsets of circulating B-lymphocytes and SARS-CoV-2 specific IgA and IgG antibodies were analyzed using a flow cytometry and immunoassays, respectively. RESULTS: Circulating plasmablasts and memory B-lymphocytes were significantly elevated and regulatory B-lymphocytes significantly decreased in the patients in comparison with 11 age- and sex-matched SARS-CoV-2 seronegative healthy adults. Next, circulating plasmablasts correlated negatively with the levels of SARS-CoV-2 specific IgG antibodies, which were detectable in 9 out of 15 tested patients. In addition, SARS-CoV-2 specific IgA antibodies were detectable in 13 of 15 tested patients and did not demonstrate correlation with any B-lymphocyte subset. CONCLUSION: Severe course of COVID-19 is associated with significant changes of phenotypes of circulating B-lymphocytes and elevated circulating plasmablasts correlate with decreased SARS-CoV-2-specific IgG antibodies (Tab. 2, Fig. 3, Ref. 14). |
||
| Keywords: COVID-19, B-lymphocytes, immunoglobulin A, immunoglobulin G | ||
| Published online: 16-Mar-2022 | ||
| Year: 2022, Volume: 123, Issue: 4 | Page From: 244, Page To: 247 | |
| doi:10.4149/BLL_2022_039 |
||
|
|
 download file |
|