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Neoplasma Vol.53, p.73-78, 2006
|Title: Comparison of NAT1, NAT2 & GSTT2-2 activities in normal and neoplastic human breast tissues|
|Author: Y.S., (GEYLAN) SU ; B., ISGOR ; T., COBAN ; N., KAPUCUOGLU ; S., AYDINTUG ; M., ISCAN ; M., ISCAN ; T., GURAY ;|
|Abstract: In this study, arylamine N-acetyltransferases, NATs (E.C.220.127.116.11)
and glutathione-S-transferase-T2-2, GSTT2-2
(E.C.18.104.22.168) enzyme activities in the breast tumor and
surrounding tumor-free tissues of 22 female breast cancer patients
with infiltrating ductal carcinoma were measured. The possible
impacts of grade of malignancy, chemotherapy treatment,
estrogen receptor status and menopausal status on all enzyme
activities were evaluated. The results showed that, both NAT2
and GSTT2-2 display significant differences between tumor and
tumor-free breast tissues, while no difference was observed
in NAT1. Grade of malignancy seems to be positively associated
with NAT1 and negatively associated with GSTT2-2.
Though, both NAT2 and GSTT2-2 have increased mean tumor
activities, the grade of malignancy, chemotherapy status,
menopausal status or estrogen receptor status are not correlated
|Keywords: breast cancer, arylamine N-acetyltransferases, NAT1, NAT2, GSTT2-2|
|Year: 2006, Volume: 53, Issue:||Page From: 73, Page To: 78|