Home Neoplasma 2006 Neoplasma Vol.53, p.73-78, 2006

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.53, p.73-78, 2006

Title: Comparison of NAT1, NAT2 & GSTT2-2 activities in normal and neoplastic human breast tissues
Author: Y.S., (GEYLAN) SU ; B., ISGOR ; T., COBAN ; N., KAPUCUOGLU ; S., AYDINTUG ; M., ISCAN ; M., ISCAN ; T., GURAY ;

Abstract: In this study, arylamine N-acetyltransferases, NATs (E.C.2.3.1.5) and glutathione-S-transferase-T2-2, GSTT2-2 (E.C.2.5.1.18) enzyme activities in the breast tumor and surrounding tumor-free tissues of 22 female breast cancer patients with infiltrating ductal carcinoma were measured. The possible impacts of grade of malignancy, chemotherapy treatment, estrogen receptor status and menopausal status on all enzyme activities were evaluated. The results showed that, both NAT2 and GSTT2-2 display significant differences between tumor and tumor-free breast tissues, while no difference was observed in NAT1. Grade of malignancy seems to be positively associated with NAT1 and negatively associated with GSTT2-2. Though, both NAT2 and GSTT2-2 have increased mean tumor activities, the grade of malignancy, chemotherapy status, menopausal status or estrogen receptor status are not correlated statistically.

Keywords: breast cancer, arylamine N-acetyltransferases, NAT1, NAT2, GSTT2-2
Year: 2006, Volume: 53, Issue: Page From: 73, Page To: 78



download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.