Home Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.5, p.362–365, 2022

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.123, No.5, p.362–365, 2022

Title: Radiobiological approach to treatment gaps in locally advanced head and neck cancers radical radiotherapy arising from the COVID-19 pandemic
Author: Camil Ciprian MIRESTEAN, Alexandru Dumitru ZARA, Roxana Irina IANCU, Dragos Petru Teodor IANCU

Abstract: Gaps of radiotherapy treatment are one of the factors recognized as unfavorable in terms of tumor control and disease prognosis. All strategies for compensating the negative effect of radiotherapy treatment gaps are based on radiobiological models. Using the modified square linear formalism (Dale`s equation) it is possible to calculate the additional dose in order to compensate the accelerated tumor repopulation effect. SARS-CoV-2 infection is an important factor that can lead to an interruption of irradiation for medium and long- term intervals. We aim to present the radiobiological data underlying the recalculation of radiotherapy treatment and exemplification for different clinical scenarios in the case of head and neck cancers (Ref. 17).

Keywords: adiobiology, treatment gaps, locally advanced head and neck cancers, radical radiotherapy, COVID-19 pandemic
Published online: 14-Apr-2022
Year: 2022, Volume: 123, Issue: 5 Page From: 362, Page To: 365

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