Home Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.6, p.444–448, 2022

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.2


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Bratislava Medical Journal Vol.123, No.6, p.444–448, 2022

Title: Are platelet indices promising ratios for predicting pediatric septic shock prognosis?
Author: Mehmet CELEGEN, Selman KESICI, Sinan YAVUZ, Kubra CELEGEN, Benan BAYRAKCI

Abstract: OBJECTIVES: The aim of the present study was to determine the prognostic value of thrombocytopenia, platelet indices (MPV/PLT and PDW/PLT) in children with septic shock.
BACKGROUND: Septic shock is one of the major causes of mortality among children worldwide.
METHODS: A retrospective analysis was made of children admitted to the pediatric intensive care unit between November 2010 and December 2019. Two hundred four children were included; they were diagnosed with septic shock according to the international pediatric sepsis consensus conference criteria. The MPV/platelet ratio and PDW/platelet ratios were estimated as the MPV and PDW values divided by the platelet count on the first three days of hospitalization. The clinical outcome was 28-day mortality.
RESULTS: MPV/PLT and PDW/PLT ratios were found to be significantly higher in the non-survivors than survivor (p≤0.001). In the multivariate logistic regression analysis, higher MPV/platelet ratios at 72h (OR: 7.41; 95% CI: 1.25–43.7; p=0.027) and PDW/platelet ratios at 72h (OR: 2.9; 95% CI: 1.13–7.50; p=0.027) were significant risk factors for mortality.
CONCLUSIONS: Platelet indices are useful laboratory parameters in septic shock. MPV/PLT and PDW/PLT ratios can be promising reliable markers for 28-day mortality in children with septic shock (Tab. 4, Fig. 1, Ref. 29).

Keywords: septic shock, mortality, platelet indices, thrombocytopenia, children
Published online: 16-May-2022
Year: 2022, Volume: 123, Issue: 6 Page From: 444, Page To: 448

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