Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.3, p. 165–190, 2022

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.41, No.3, p. 165–190, 2022

Title: Transient receptor potential vanilloid (TRPV) channels: Basal properties and physiological potential
Author: Tomohiko Sasase, Fatchiyah Fatchiyah, Takeshi Ohta

Abstract: Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies targeting human diseases. TRPV channels play crucial roles in normal physiological processes, and their dysfunction has been implicated in various disease states. Several small-molecule compounds, such as TRPV1 and TRPV3 antagonists, have been developed as novel analgesic agents. A better understanding of the physiological functions of TRPV channels would lead to progress in life science. In this review, we focus on various functions of TRPV channels, including pain sensing, temperature sensing, and metabolic control, as well as summarize the basal properties and pathophysiological contributions of six TRPV channels. Moreover, we discuss the pharmacological effects of endogenous and exogenous ligands on TRPV channels and related diseases.

Keywords: TRPV channels — Sensory system — Channel diseases — Drug discovery
Published online: 23-May-2022
Year: 2022, Volume: 41, Issue: 3 Page From: 165, Page To: 190
doi:10.4149/gpb_2022016


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