Home 
CUSTOMERS General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.3, p. 191–203, 2022
CUSTOMERS General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.3, p. 191–203, 2022
Journal info
Aims and Scope |
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.41, No.3, p. 191–203, 2022 |
||
| Title: Investigation of the key targets and pharmacological mechanisms of rhamnocitrin against oxaliplatin-induced neuropathic pain based on network pharmacology approach and experimental validation | ||
| Author: Xianbin Cai, Xuefen Xu | ||
| Abstract: Rhamnocitrin (RH) is a bioactive flavonoid of Astragali Radix, which exerts a wide variety of pharmacological effects. However, there are no reports focusing on the therapeutical effects and mechanisms of RH against neuropathic pain (NP). In this study, systematic pharmacology and in vivo experimental approaches were employed to identify the potential targets of RH for treating oxaliplatin-induced NP. Our findings indicated that the therapeutical effect of RH might be closely associated with key genes, including MAPK3, MAPK1, SRC, PTGS2, EGFR, MMP9, and MMP2, as well as potential signaling pathways such as PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance, and Rap1 signaling pathway. The in vivo experimental findings demonstrated that RH could suppress oxidative stress, inflammatory response, and down-regulate MMP2 and MMP9 expressions to exert its therapeutic effects against NP. This study used network pharmacology and experimental validation to elucidate the potential targets and underlying mechanisms by which RH improves oxaliplatin-induced NP and offer new insight on drug development for NP. |
||
| Keywords: Rhamnocitrin — Oxidative stress — Oxaliplatin — Neuropathic pain — Astragali radix | ||
| Published online: 23-May-2022 | ||
| Year: 2022, Volume: 41, Issue: 3 | Page From: 191, Page To: 203 | |
| doi:10.4149/gpb_2022015 |
||
|
|
 download file |
|