Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.3, p. 245–253, 2022

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Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.41, No.3, p. 245–253, 2022

Title: Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol
Author: Abdurrahman Ekici, Esra Gürbüz, Mehmet Berköz, Ömer Türkmen, Yıldıray Başbuğan, Oruç Yunusoğlu

Abstract: Alcohol addiction or alcoholism constitutes a significant risk factor worldwide for morbidity and mortality. Moxidectin is a recently approved anthelmintic drug, which also activates the gamma-aminobutyric acid receptors. The objective of the present study was to examine the impact of moxidectin on rewarding effects of ethanol in the conditioned place preference (CPP) model in mice. In separate experiments, mice were administered intraperitoneal (i.p.) injections of moxidectin (5 or 10 mg/kg) before a) acquisition of alcohol-induced CPP, b) each extinction session, and c) alcohol-induced reinstatement of CPP. The present experiments provide consistent data about ethanol place preference in mice (2 g/kg, i.p.), with mice in all tests spending significantly more time on the ethanol-paired side. The acquisition of the CPP response to ethanol was prevented by the administration of moxidectin at a dose of 10 mg/kg. Additionally, moxidectin treatment accelerated the extinction of ethanol CPP when given repeatedly during the extinction phase. Ethanol-induced reinstatement of CPP following an extinction phase was inhibited by moxidectin. Ethanol alone and co-administration with moxidectin did not change locomotor activity and motor coordination. In conclusion, we suggest that moxidectin may be a promising therapeutic candidate for prevention of ethanol-induced addiction and relapse as well as detoxification.



Keywords: Alcohol addiction — Moxidectin — Conditioned place preference — Mice
Published online: 23-May-2022
Year: 2022, Volume: 41, Issue: 3 Page From: 245, Page To: 253
doi:10.4149/gpb_2022014


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