Home CUSTOMERS Acta Virologica 2022 Acta Virologica Vol.66, No.2, p. 101 – 109, 2022

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.66, No.2, p. 101 – 109, 2022

Title: Apoptosis mechanisms induced by parvovirus infections
Author: Ruth Afumba, Jun-Ting Liu, Hao Dong

Abstract: Parvoviruses affect both vertebrates and invertebrates, and can be both detrimental and benign to the host. Numerous studies about parvovirus-induced apoptotic cell death have been researched and reported. In most parvovirus infections, cell death heightens the virus dissemination and causes tissue damage, often leading to disease. Cell cycle arrest also induces cytopathic effects in infected cells and is sometimes a prerequisite to apoptotic cell death. Cell death mechanisms caused by parvovirus infections vary depending on the infecting parvovirus strain and the cell lines involved. Apo-
ptosis, however, is a frequent form of cell death induced by parvoviruses. The non-structural protein 1 (NS1) is a major contributor to parvovirus infection-induced cell death. However, other proteins such as the 11 kDa, NP1 and viral genome replication can also induce cell death. Understanding the mechanisms involved in parvovirus cell death, and host response is important in the development of treatment for cytopathic parvoviruses. This review article discusses parvovirus-induced apoptotic cell death and the mechanisms involved.

Keywords: apoptosis; cell cycle arrest; cell death; parvovirus; viral protein
Published online: 29-Jun-2022
Year: 2022, Volume: 66, Issue: 2 Page From: 101, Page To: 109
doi:10.4149/av_2022_210
Price: 21.60 €






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