Acta Virologica Vol.66, No.2, p. 166

Acta Virologica Vol.66, No.2, p. 166 – 173, 2022

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.66, No.2, p. 166 – 173, 2022
Title: Curcumin inhibits the replication of rotavirus in vitro
Author: Mina Hassanpour, Abbas Tazarghi, Ali Teimoori, Alijan Tabaraei, Vahid Erfani-Moghadam, Ahad Yamchi, Sedigheh Akhondi, Hadi Razavi Nikoo

Abstract: Rotavirus is the most important etiological agent of infectious diarrhea in children under 5 years of age with more than 125,000 deaths occurring annually worldwide. The present study aims to determine the effect of curcumin, a natural polyphenol compound, on rotavirus in a cell culture model. The anti-viral activity of curcumin was evaluated by reverse-transcriptase quantitative PCR (RT-qPCR), TCID50, and western blot techniques to assess CC50 in curcumin-treated MA104 cells as well as EC50 and SI within the infected MA104 cell line. Our findings supported that curcumin exerted an inhibitory influence against rotavirus in a dose-dependent manner and decreased the viral titer and VP6 expression by ~99% at a concentration of 30 μM (p

Keywords: curcumin; rotavirus; RT-qPCR; in vitro; anti-rotavirus agent
	Published online: 29-Jun-2022
Year: 2022, Volume: 66, Issue: 2	Page From: 166, Page To: 171
doi:10.4149/av_2022_206
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