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General Physiology and Biophysics Vol.41, No.4, p. 275–286, 2022 |
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Title: Remote conditioning as protective strategy influencing ubiquitin-mediated stress response in the rabbit spinal cord after ischemia/reperfusion | ||
Author: Marianna Danková, Iveta Domoráková, Zuzana Fagová, Milan Stebnický, Eva Mechírová, Štefan Polák | ||
Abstract: The aim of presented study was to investigate the model of non-invasive method of remote conditioning induced by compression of left forelimb with a tourniquet in three cycles of 2 min of ischemia each followed by 2 min of reperfusion and its influence on the rabbit spinal cord ischemia/reperfusion injury via ubiquitin-mediated stress response. Ubiquitin immunoreaction in spinal cord motor neurons as well as detection of neuronal survival in ventral horns of spinal cord were evaluated. Significantly increased (p t remote conditioning significantly attenuated degeneration of motor neurons in all conditioned groups versus SC-ischemia groups in each time point. According to our results, we concluded that the remote conditioning induced by transient limb ischemia is relevant stimulus that provides potent neuroprotection in a model of spinal cord ischemia/reperfusion injury. |
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Keywords: Ischemia/reperfusion injury — Rabbit — Remote conditioning — Spinal cord — Ubiquitin | ||
Published online: 28-Jul-2022 | ||
Year: 2022, Volume: 41, Issue: 4 | Page From: 275, Page To: 286 | |
doi:10.4149/gpb_2022021 |
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