Home Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.11, p.846–852, 2022

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.123, No.11, p.846–852, 2022

Title: Assessment of the role of neutrophil extracellular traps in SARS-CoV-2 pneumonia
Author: Fatih CAKMAK, Seda OZKAN, Dildar KONUKOGLU, Serap BIBEROGLU, Afsin IPEKCI, Yonca Senem AKDENIZ, Ibrahim Murat BOLAYIRLI, Ilker Inanc BALKAN, Guleren Yartas DUMANLI, Ibrahim IKIZCELI

Abstract: BACKGROUND: Abnormal neutrophil extracellular traps are associated with lung diseases, thrombosis, increased mucosal secretion in the airways. The aim of this study is to evaluate the possible place of the most specific NETosis marker Cit-H3 protein in diagnostic algorithms by revealing its relationship with the severity, mortality and prognosis of SARS-CoV-2 pneumonia.
PATIENTS AND METHODS: Patients (n = 78) who applied to the Emergency Department between March 11, 2020 and June 10, 2020, with positive SARS-CoV-2 polymerase chain reaction (PCR) test and lung involvement were included in the prospective study. Serum Cit-H3 levels and critical laboratory parameters were measured at baseline on the day of clinical deterioration and before recovery/discharge/death. Cit-C3 levels were determined by enzyme immunassay method.
RESULTS: Cit-H3 levels in patients with SARS-CoV-2 pneumonia during their first admission to the hospital were significantly higher compared to the healthy control group (p < 0.05). Repeated measurements of Cit-H3 levels of the patients significantly correlated with D-dimer, procalcitonin, Neutrophil/ Lymphocyte ratio, lymphocyte, CRP, and oxygen saturation. Cit-H3 levels of the patients who died were significantly higher than that of those who survived (p < 0.05). Cit-H3 levels were found to be statistically significantly higher in patients who developed acute respiratory distress syndrome, were admitted to the intensive care unit, and had mortality (p < 0.05).
CONCLUSIONS: Cit-H3 plays a role in inflammatory processes in SARS-CoV-2 pneumonia, and changes in serum Cit-H3 levels of these patients can be used to determine prognosis and mortality (Tab. 5, Fig. 1, Ref. 21).

Keywords: SARS-CoV-2, pneumonia, NETosis, citrullinated histone H3, biomarker, emergency medicine
Published online: 26-Aug-2022
Year: 2022, Volume: 123, Issue: 11 Page From: 846, Page To: 852

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