Acta Virologica Vol.66, No.3, p. 216

Acta Virologica Vol.66, No.3, p. 216 – 227, 2022

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

Impact Factor = 1.82

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Acta Virologica Vol.66, No.3, p. 216 – 227, 2022
Title: A gene expression signature that correlates with CD8+T cell expansion in acute Epstein-Barr virus infection
Author: Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo

Abstract: Acute infectious mononucleosis (AIM) is associated with Epstein-Barr virus (EBV) infection. We explored molecular mechanisms regarding the expression of CD8+T cells in convalescence stage (CONV). Differentially expressed genes (DEGs) were identified by analyzing GEO expression profiles. Subsequently, Gene Set Enrichment Analysis (GSEA), Protein-Protein Interactions (PPI) network, and gene-micro RNAs networks were used to identify hub genes and associated pathways. GSEA provided evidence that the top 3 gene sets in GSEA were all related to integrins. We identified ten hub genes in the PPI network and DGIdb was applied to predict potential targets that might reverse the expression of hub genes. Our study enhances a mechanistic understanding of the CD8+T cells expansion in acute EBV infection and provides potential treatment targets for further research.

Keywords: acute infectious mononucleosis; bioinformatics; CD8+T cells; differentially expressed genes; EBV
	Published online: 27-Aug-2022
Year: 2022, Volume: 66, Issue: 3	Page From: 216, Page To: 227
doi:10.4149/av_2022_303
	download file

Aepress.sk