Home 
Neoplasma Ahead of print Neoplasma Vol.69, No.6, p. 1277–1288, 2022
Neoplasma Ahead of print Neoplasma Vol.69, No.6, p. 1277–1288, 2022
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.69, No.6, p. 1277–1288, 2022 |
||
| Title: Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer | ||
| Author: Meng Zhang, Wen-Bin Guan, Jun-Lei Li, Ling-Xuan Li, Ke-Zhou Wang, Rui-Fen Wang, Li-Feng Wang | ||
| Abstract: Gastric cancer (GC) is the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide. Cancer-associated fibroblasts (CAFs), an important cell type in the tumor microenvironment, play an important role in GC development. In this review, we describe the current knowledge of CAFs' heterogeneity and their role in GC invasion and metastasis. Currently, CAF-targeted cancer therapies are being rapidly explored and developed. However, the heterogeneity of CAFs limits the application of this therapy, so it is urgent to find specific markers and divide them into different subpopulations. With the development of single-cell RNA sequencing technology, researchers have used this technology to classify CAFs in many tumors, but whether it is applicable to GC and other tumors needs further study. And we believe that this technology will be in the near future utilized to sort CAFs on the basis of different cell markers and functions, so as to target tumor-promoting CAFs and inhibit tumor progression. Targeting CAFs by cell surface markers or normalizing the activated CAFs subsets may be an effective therapy, alone or in combination with other therapeutic approaches for GC treatment. Therefore, in the coming decades, the interaction between CAFs and GC cells will be still the focus of our research. |
||
| Keywords: cancer-associated fibroblasts; gastric cancer; subtypes; invasion and metastasis | ||
| Published online: 02-Sep-2022 | ||
| Year: 2022, Volume: 69, Issue: 6 | Page From: 1277, Page To: 1288 | |
| doi:10.4149/neo_2022_220513N511 |
||
|
|
 download file |
|