Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.5, p. 417–430, 2022

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.41, No.5, p. 417–430, 2022

Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II
Author: Paulína Pidíková, Barbora Chovancová, Boris Mravec, Iveta Herichová
Abstract: Study was focused on regulatory interactions between the circadian system and the renin–angiotensin system in control of microRNA (miRNA) biosynthesis. Responsiveness of the miRNA biosynthetic pathway, selected pre-miRNAs and clock genes to angiotensin II (AngII) infusion was analysed in the suprachiasmatic nuclei (SCN), liver, kidney and heart during a 24-h cycle. per2 exerted a rhythmic expression profile in all analysed tissues. clock expression showed a rhythmic pattern in the peripheral tissues with tissue-specific response to AngII. dgcr8 expression showed a tissue-specific rhythm only in peripheral tissues, which diminished in the heart and kidney after AngII delivery. Expression of pre-miR-30c was rhythmic in all studied peripheral tissues, pre-miR-34a expression exerted significant rhythm only in the liver. AngII delivery increased expression of pre-miR-30c and pre-miR-34a in the kidney. To conclude, peripheral oscillators are more likely to exhibit rhythmic miRNA biosynthesis responsive to AngII in a tissue-specific manner compared to SCN.
Keywords: clock — miR-34a — miR-30c — Liver — Kidney
Published online: 27-Sep-2022
Year: 2022, Volume: 41, Issue: 5 Page From: 417, Page To: 430
doi:10.4149/gpb_2022033


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