Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.6, p. 523–533, 2022

Journal info


Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.41, No.6, p. 523–533, 2022

Title: Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length
Author: Dominika Hajduchova, Roman Holic, Peter Gajdos, Milan Certik, Erika Halasova, Renata Pecova, Michal Pokusa
Abstract: Events associated with the progression of Parkinson´s disease (PD) are closely related to biomembrane dysfunction. The specific role of membrane composition in the conformational stability of alpha synuclein (αS) has already been well documented. Administration of rotenone is one of the best strategies to initiate PD phenotype in animal models. In the present study, daily exposure (14 weeks) of orally administered rotenone (10 mg/kg) was employed in a mouse model. The mitochondrial complex I inhibition resulted in elevated level of αS in whole tissue homogenate of mouse jejunum. In addition, we identified a strong intra-individual correlation between αS level and the specific esterified fatty acids. The observed correlation depends mainly on the acyl chain length. Based on the obtained results, it is suggested that there is a high potential to manipulate fatty acid homeostasis in modulating αS based pathogenesis of PD, at least in experimental conditions.
Keywords: Parkinson’s disease — Alpha synuclein — Gastrointestinal tract — Fatty acids — Mitochondrial complex I inhibition
Published online: 23-Nov-2022
Year: 2022, Volume: 41, Issue: 6 Page From: 523, Page To: 533
doi:10.4149/gpb_2022046


download file


© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.