Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.6, p. 523–533, 2022

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Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.41, No.6, p. 523–533, 2022

Title: Correlation between α-synuclein and fatty acid composition in jejunum of rotenone-treated mice is dependent on acyl chain length
Author: Dominika Hajduchova, Roman Holic, Peter Gajdos, Milan Certik, Erika Halasova, Renata Pecova, Michal Pokusa

Abstract: Events associated with the progression of Parkinson´s disease (PD) are closely related to biomembrane dysfunction. The specific role of membrane composition in the conformational stability of alpha synuclein (αS) has already been well documented. Administration of rotenone is one of the best strategies to initiate PD phenotype in animal models. In the present study, daily exposure (14 weeks) of orally administered rotenone (10 mg/kg) was employed in a mouse model. The mitochondrial complex I inhibition resulted in elevated level of αS in whole tissue homogenate of mouse jejunum. In addition, we identified a strong intra-individual correlation between αS level and the specific esterified fatty acids. The observed correlation depends mainly on the acyl chain length. Based on the obtained results, it is suggested that there is a high potential to manipulate fatty acid homeostasis in modulating αS based pathogenesis of PD, at least in experimental conditions.

Keywords: Parkinson’s disease — Alpha synuclein — Gastrointestinal tract — Fatty acids — Mitochondrial complex I inhibition
Published online: 23-Nov-2022
Year: 2022, Volume: 41, Issue: 6 Page From: 523, Page To: 533

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