Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.6, p. 549–558, 2022

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.41, No.6, p. 549–558, 2022

Title: Plasma proteome alterations in prediabetic, obese Zucker rats – possible cardiovascular risk implications
Author: Justyna Totoń-Żurańska, Lucia Balazova, Katarina Krskova, Beata Bujak-Giżycka, Stefan Zorad, Rafał Olszanecki, Maciej Suski
Abstract: Hyperphagia and obesity, which underlie metabolic syndrome, have been linked to multiple health complications and increased mortality. Here, we investigate the differences in plasma proteome between obese and lean Zucker rats in order to identify circulating proteins involved in obesity-related conditions. Plasma samples of male Zucker fatty (obese) rats carrying fatty fa/fa mutation (–/–) and their lean controls were enriched using ProteoMiner technology and labeled with isobaric tags (iTRAQ) for mass spectrometry-based quantitation. We found elevation in levels of coagulation factors whereas levels of serine protease inhibitors were decreased. Levels of acute phase proteins were also altered, as well as complement components. We also noticed differences in the abundance of apolipoproteins. In summary, quantitative proteomic assessment of plasma protein composition in obese Zucker rats revealed a profound landscape of changes, reflecting altered hemostasis, disturbed metabolic processes involving insulin resistance and lipid metabolism and ongoing low-grade inflammation.
Keywords: Obesity — Metabolic syndrome — Thrombophilia — Inflammation — Proteomics
Published online: 23-Nov-2022
Year: 2022, Volume: 41, Issue: 6 Page From: 549, Page To: 558
doi:10.4149/gpb_2022043


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