Home Neoplasma 2023 Neoplasma Vol.70, No.1, p. 166–176, 2023

Journal info

6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.70, No.1, p. 166–176, 2023

Title: BDNF, sHLA-G, and sTREM-1 are useful blood biomarkers for identifying grade IV glioma patients
Author: Kristina Kluckova, Jan Kozak, Marian Svajdler, Juraj Steno, Viktor Matejcik, Vladimira Durmanova, Eszter Zsemlye, Maria Bucova

Abstract: Inflammation and immunity belong to the main factors influencing tumor growth. In this study, we attempted to identify a profile of biomarkers associated with gliomas. We found decreased serum levels of sTREM-1 (soluble triggering receptor expressed on myelocytes) and increased levels of IL-10 in all grades of glioma patients in comparison with healthy controls (sTREM-1: grade II: p = 0.0051, grade III: p = 0.02, grade IV: p = 0.01; IL-10: grade II: p = 0.0017, grade III: p = 0.03, grade IV: p = 0.007). However, we did not find any combination of tested markers with good sensitivity and specificity in grades II and III of glioma patients to discriminate them from healthy controls. In grade IV glioma patients, two sets of markers showed promising results in distinguishing patients from healthy people. For the first set consisting of four selected markers, sTREM-1, sHLA-G, BDNF, and IL-13, the ROC curves indicate a good discriminatory capability for glioblastoma patients (AUC = 0.9510). The best discriminatory capability for glioblastoma patients (AUC = 0.9534) was found for the second set consisting of three selected markers sTREM-1, sHLA-G, and BDNF with 79.2% sensitivity and 94.1% specificity.

Keywords: BDNF; HLA-G; TREM-1; IL-13; glioma
Published online: 27-Jan-2023
Year: 2023, Volume: 70, Issue: 1 Page From: 166, Page To: 176

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.