Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.1, p 25–36, 2023

Journal info

Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

Aims and Scope
Editorial Info
Abstracting and Indexing
Submission Guidelines

Select Journal

Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.42, No.1, p 25–36, 2023

Title: High-fructose intake-induced dyslipidemia and oxidative stress accompanied by hippocampal dysfunctions in hypertensive but not hypertriacylglycerolemic rats
Author: Zdenka Gasparova, Euridika Ruskova, Dominika Seckarova Michalikova , Zuzana Brnoliakova, Karol Svik, Lukas Slovak, Stefan Bezek, Vladimir Knezl, Ruzena Sotnikova

Abstract: A high-fructose intake is metabolically analogous to a high-fat diet. The impact of high-fructose intake was investigated in spontaneously hypertensive (SHR) and hypertriacylglycerolemic (HTG) rats to find out the impact of which risk factor of metabolic syndrome – hypertension or hypertriacylglycerolemia – will cause more complications. Rats were fed a standard or a fructose diet (F60) with 60% of added fructose for 5 weeks. The F60 diet increased the total serum cholesterol content of both HTG-F60 and SHR-F60 rats. Further, in SHR-F60 it increased serum triacylglycerols, TBARS in the liver, a specific activity of NAGA in the kidney, aggravated glucose tolerance, deteriorated synaptic plasticity, and reduced somatic and dendritic responses in the hippocampus. SHR rats were more sensitive to the F60 diet, suggesting that hypertension along with a high-fructose intake result in a more pronounced disorder compared to hypertriacylglycerolemia. This work wants to draw attention to fructose-induced health risks associated with hypertension.

Keywords: Fructose — Oxidative stress — Lipid profile — Hypertension — Synaptic plasticity
Published online: 30-Jan-2023
Year: 2023, Volume: 42, Issue: 1 Page From: 25, Page To: 36

download file

© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.