Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.1, p 59–66, 2023

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.42, No.1, p 59–66, 2023

Title: Anionic lipids modulate little the reorganization effect of amyloid-beta peptides on membranes
Author: Oleksandr Ivankov, Dina R. Badreeva, Elena V. Ermakova, Tomáš Kondela, Tatiana N. Murugova, Norbert Kučerka

Abstract: Amyloid-β peptide interactions with model lipid membranes have been studied by means of small angle neutron scattering and molecular dynamics simulations. These interactions had been indicated recently as an origin of the membrane structure reorganizations between spherical small unilamellar vesicles and planar bicelle-like structures. In present work, we investigate the influence of charge on the peptide-triggered morphological changes by introducing the anionic lipid DMPS to the underlying DMPC membrane. Changes to the membrane thickness and the overall membrane structure with and without Aβ25–35 incorporated have been investigated over a wide range of temperatures. Our results document the previously reported morphological reformations between bicelle-like structures present in gel phase and small unilamellar vesicles present in fluid phase to be independent from the charge existence in the system.

Keywords: Amyloid-β peptide — Anionic phosphatidylcholine membrane — Lipid phase transition — Peptide-lipid interactions — Small angle neutron scattering — Molecular dynamics
Published online: 30-Jan-2023
Year: 2023, Volume: 42, Issue: 1 Page From: 59, Page To: 66

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