General Physiology and Biophysics Vol.42, No.1, p 87

General Physiology and Biophysics Vol.42, No.1, p 87–95, 2023

Quarterly, 80 pp. per issue
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ISSN 1338-4325 (online)

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General Physiology and Biophysics Vol.42, No.1, p 87–95, 2023
Title: Effect on hypoxia/reoxygenation-induced cardiomyocyte injury and Pink1/Parkin pathway
Author: Xiyang Lu, Guangwei Huang, Hailong Bao, Zonggang Duan, Chao Li, Muzhi Lin, Haiyan Zhou, Zhenhua Luo Wei Li

Abstract: Our study aimed to detect the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) on exacerbating cardiomyocyte hypoxia/reoxygenation (H/R) injury and the possible mechanism. A cell model of H/R was constructed. PCSK9 mRNA and protein levels were significantly upregulated during AC16 cardiomyocyte H/R. Flowmetry detection of apoptosis, as well as JC-1, confirmed that PCSK9 upregulation of autophagy levels was accompanied by apoptosis. Furthermore, in the H/R+si-PCSK9 group, the expression of autophagy-related protein LC3 decreased and P62 increased. At the same time, the presentation of the autophagic pathway Pink1/Parkin was also downregulated. In conclusion, in AC16 cardiomyocytes treated with H/R, PCSK9 expression and autophagy levels were increased; a possible molecular mechanism was the activation of the Pink1/Parkin pathway.

Keywords: PCSK9 — Pink1/Parkin — Small interfering RNA — Autophagy — Cardiomyocyte cytology
	Published online: 30-Jan-2023
Year: 2023, Volume: 42, Issue: 1	Page From: 87, Page To: 95
doi:10.4149/gpb_2022045
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