Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.1, p 97–106, 2023

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.42, No.1, p 97–106, 2023

Title: Cytoprotective effects of low-frequency pulsed electromagnetic field against oxidative stress in glioblastoma cells
Author: Çiğdem Gökçek-Saraç, Tuğçe Şimşek, Serdar Karakurt
Abstract: The low-frequency pulsed electromagnetic field (PEMF) may have possible cytoprotective effects against the destructive effects of oxidative stress. The goal was to investigate if short-term low-frequency PEMF has cytoprotective effects in glioblastoma cell line following high-dose hydrogen peroxide (H2O2) treatment. U87-MG cells were divided into four groups: Sham-control group; PEMF group (cells exposed to PEMF); H2O2 group (cells treated with H2O2 at time intervals 30 min and 48 h, respectively); H2O2+PEMF group (cells exposed to PEMF after H2O2 treatment at time intervals 30 min and 48 h, respectively). The cell viability, levels of reactive oxygen species, glutathione peroxidase activity, and the amount of glutathione were measured. The cytoprotective effect of PEMF against deleterious effects of oxidative stress triggered by different time interval of H2O2 treatment might be mediated by the increase in the cell viability, the elevation in the antioxidant enzyme activity/amount, and the decrease in the reactive oxygen species level. In addition, the cytoprotective effect of PEMF varies depending on different time intervals of H2O2 treatment. In the light of these findings, further in vivo and/or in vitro studies on neurophysiological effects of PEMFs and their underlying molecular mechanisms are needed to elucidate neurotoxic or neuroprotective role against antioxidant defense mechanisms.
Keywords: Pulsed electromagnetic field — U87-MG cells — Oxidative stress — Reactive oxygen species — Antioxidants
Published online: 30-Jan-2023
Year: 2023, Volume: 42, Issue: 1 Page From: 97, Page To: 106
doi:10.4149/gpb_2022056


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