Home 
Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.124, No.5, p.368–372, 2023
Bratislava Medical Journal Ahead of print Bratislava Medical Journal Vol.124, No.5, p.368–372, 2023
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.124, No.5, p.368–372, 2023 |
||
| Title: Plasmatic apelin shows a promising potential as a screening biomarker for atrial fibrillation | ||
| Author: Branislav BEZAK, Peter SNOPEK, Lubomira TOTHOVA, Nikola JAJCAY, Viliam MOJTO, Stefan FARSKY, Karin GMITTEROVA, Marek KRIVOSIK, Simona STANKOVA, Olga DURANIKOVA, Marta KOLLAROVA, Katarina PETRIKOVA, Allan BOHM | ||
| Abstract: OBJECTIVES: Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients. BACKGROUND: AF is the most common cardiac arrhythmia with constantly increasing incidence and prevalence. Currently available diagnostic tools do not provide sufficient detection rate. Large proportion of patients with AF remains undiagnosed and the possibility of screening at-risk groups would be significantly beneficial. METHODS: We designed this study as a multi-centre retrospective study. Study population included 183 patients. 64 in non-AF and 119 in AF group. RESULTS: Apelin plasma concentration was significantly lower in AF group compared to non-AF group (p < 0.001). Receiver operating characteristic analysis of apelin as a predictor of AF scored area under the curve of 0.79, sensitivity = 0.941 and specificity = 0.578. Multivariate analysis using logistic regression adjusted for age, BMI, apelin, dilated LV, dilated LA, arterial hypertension, and gender showed only apelin and age to be statistically significant contributors for AF. CONCLUSION: Apelin might be a promising biomarker for detecting AF in our study population. These results suggest promising potential of apelin as a screening biomarker for AF (Tab. 2, Fig. 1, Ref. 46). Text in PDF www.elis.sk |
||
| Keywords: biomarker, apelin, arrhythmia, atrial fibrillation | ||
| Published online: 27-Feb-2023 | ||
| Year: 2023, Volume: 124, Issue: 5 | Page From: 368, Page To: 372 | |
| doi:10.4149/BLL_2023_056 |
||
|
|
 download file |
|