Home Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.6, p.417–420, 2023

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.124, No.6, p.417–420, 2023

Title: Autovaccines – potent tool against chronic vulvovaginal candidiasis
Author: Jan KOREN, Magdalena ZABORSKA, Ivan VARGA, Jozef ZAHUMENSKY, Adriana LIPTAKOVA

Abstract: OBJECTIVE: Our aim was to determine the effect of immunomodulatory therapy in women with chronic and recurrent vulvovaginal candidiasis (RVVC).
BACKGROUND: We present recent highlights in the research into vaginal microbiome and consequences of chronic inflammation such as vulvovaginal candidiasis (VVC). VVC is a widespread vaginal infection primarily caused by Candida albicans. Experience of more than three episodes per year is defined as RVVC.
METHODS: The strains were isolated from women suffering from the above infections as for the period of 2017 to 2021 and subsequently used in immunomodulatory treatment. The preparation and administration of autovaccination therapy was performed using standard methodology and procedures cited in the manuscript.
RESULTS: In total, autovaccines were produced for 73 patients of whom 30 (41 %) were successfully cured by this treatment, 29 (40 %) experienced a partially successful treatment, and in the remaining 14 (19 %), the autovaccination therapy was ineffective.
CONCLUSION: We provide current knowledge about alternative (autovaccine) treatment options for female patients with VVC and RVVC diseases and our experience with the outcomes after autovaccine administration that currently has a promising therapeutic potential (Tab. 2, Ref. 18). Text in PDF www.elis.sk

Keywords: autovaccines, chronic infections, vulvovaginal candidiasis, recurrent, Candida albicans
Published online: 28-Feb-2023
Year: 2023, Volume: 124, Issue: 6 Page From: 417, Page To: 420

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