Home CONTACT Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.6, p.471–474, 2023

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.124, No.6, p.471–474, 2023

Title: Neutrophil/lymphocyte, platelet/lymphocyte, monocyte/lymphocyte ratios and systemic immune-inflammation index in patients with depression
Author: Xiaoyu ZHU, Ran LI, Yu ZHU, Jia ZHOU, Xiaole HAN, Yongsheng TONG, Yunlong TAN
Abstract: BACKGROUND: Evidence suggest immunity abnormalities and inflammation might play an important role in the pathophysiology of depression. This study explored the relationship between inflammation and depression using neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) as inflammatory markers.
METHODS: We collected the full blood count results of 239 patients with depression and 241 healthy controls. Patients were divided into three diagnostic subtype groups: severe depressive disorder with psychotic symptoms, severe depressive disorder without psychotic symptoms, and moderate depressive disorder. We analyzed the Participants’ neutrophil (NEU), lymphocyte (LYM), monocyte (MON), and platelet (PLT) counts, compared the differences in NLR, MLR, PLR and SII, and explored the relationships between depression and these indicators.
RESULTS: There were significant differences in PLT, MON, NEU, MLR, and SII among the four groups. MON and MLR were significantly higher in three groups of depressive disorders. SII was significantly increased in two severe depressive disorder groups, while the SII in the moderate depressive disorder group showed an increasing trend.
CONCLUSION: Increased MON, MLR and SII, as signs of inflammatory response, were not different among three subtypes of depressive disorders, and may be biological indictors of depressive disorders (Tab. 1, Ref. 17). Text in PDF www.elis.sk
Keywords: depression, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII)
Published online: 28-Feb-2023
Year: 2023, Volume: 124, Issue: 6 Page From: 471, Page To: 474
doi:10.4149/BLL_2023_072


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