Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.2, p. 179–190, 2023

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.42, No.2, p. 179–190, 2023

Title: The role of NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms in endothelial dysfunction pathway and carotid intima-media thickness in hypertensive patients
Author: Andrii Sydorchuk, Larysa Sydorchuk, Adelina Gutnitska, Valentina Vasyuk, Oleksii Tkachuk, Valentina Dzhuryak, Yuriy Myshkovskii, Petro Kyfiak, Ruslan Sydorchuk, Oksana Iftoda

Abstract: The mechanisms orchestrating the balance between nitric oxide and endothelium-derived contracting factors, and genetic predisposition to endothelial dysfunction in hypertensive patients remain to be determined. One-hundred hypertensive patients participated in the case-control study to clarify the risk of endothelial dysfunction and carotid “intima media” thickness (IMT) changes depending on NOS3 (rs2070744) and GNB3 (rs5443) genes’ polymorphisms. It is found that presence of NOS3 gene’s С-allele significantly elevates the risk of atherosclerotic plaques on carotid arteries (OR95%CI: 1.24–11.20; р = 0.019) and the probability of low NOS3 gene expression (OR95%CI: 17.72–520.0; р < 0.001). Homozygous carriage of С-allele of GNB3 gene is protective and corresponds to the lowest chances of the carotid IMT increase, atherosclerotic plaques formation and sVCAM-1 elevation (OR = 0.10–0.34; OR95%CI: 0.03–0.95; р ≤ 0.035–0.001). Vice versa, Т-allele of GNB3 gene significantly augments the risk of the carotid IMT increase (OR95%CI: 1.09–7.74; р = 0.027) including development of atherosclerotic plaques, associating GNB3 (rs5443) with cardiovascular pathology.

Keywords: Endothelial dysfunction — Hypertension risk — NOS3 (rs2070744), GNB3 (rs5443) genes’ polymorphism
Published online: 14-Mar-2023
Year: 2023, Volume: 42, Issue: 2 Page From: 179, Page To: 190

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