Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.2, p. 201–208, 2023

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.42, No.2, p. 201–208, 2023

Title: Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats
Author: Alparslan Koç, Mustafa Gazi, Ali Caner Sayar, Didem Onk, Muhammet Ali Arı, Bahadır Süleyman, Ahmet Gökhan Ağgül, Fikret Altındağ, Durdu Altuner,Halis Süleyman
Abstract: Toxic doses of paracetamol are also known to be close to therapeutic doses. This study aimed to biochemically investigate the protective effect of ATP against paracetamol-induced oxidative liver injury in rats and to examine the tissues histopathologically. We divided the animals into the paracetamol alone (PCT), ATP + paracetamol (PATP), and healthy control (HG) groups. Liver tissues were examined biochemically and histopathologically. Malondialdehyde level, AST and ALT activity in the PCT group were significantly higher than those in the HG and PATP groups (p < 0.001). The glutathione (tGSH) level, superoxide dismutase (SOD) and catalase (CAT) activity in the PCT group was significantly lower than that in the HG and PATP groups (p < 0.001), while animal SOD activity was significantly different between the PATP and HG groups (p < 0.001). The activity of CAT was almost the same. In the group treated with paracetamol alone, lipid deposition, necrosis, fibrosis, and grade 3 hydropic degeneration were observed. No histopathological damage was observed of the ATP-treated group, except for grade 2 edema. We discovered that ATP reduces the oxidative stress caused by paracetamol ingestion and protects against paracetamol-induced liver injury at the macroscopic and histological levels.
Keywords: Paracetamol — Liver toxicity — ATP — Pain
Published online: 14-Mar-2023
Year: 2023, Volume: 42, Issue: 2 Page From: 201, Page To: 208
doi:10.4149/gpb_2022055


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