Home 
CONTACT Acta Virologica 2023 Acta Virologica Vol.67, No.1, p. 99 – 108, 2023
CONTACT Acta Virologica 2023 Acta Virologica Vol.67, No.1, p. 99 – 108, 2023
Journal info
Aims and Scope |
||
Select Journal
Journals
Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.67, No.1, p. 99 – 108, 2023 |
||
| Title: Kinetics of interferon-λ and receptor expression in response to in vitro respiratory viral infection | ||
| Author: Alexey A. Lozhkov, Nikita D. Yolshin, Irina L. Baranovskaya, Marina A. Plotnikova, Maria V. Sergeeva, Natalia E. Gyulikhandanova, Sergey A. Klotchenko, Andrey V. Vasin | ||
| Abstract: The major protective immune response against viruses is the production of type I and III interferons (IFNs). IFNs induce the expression of hundreds of IFN-stimulated genes (ISGs) that block viral replication and further viral spread. In this report, we analyzed the expression of IFNs and some ISGs (MxA, PKR, OAS-1, IFIT-1, RIG-1, MDA5, SOCS-1) in alveolar epithelial cells (A549) in response to infection with influenza A viruses (A/California/07/09 (H1N1pdm); A/Texas/50/12 (H3N2)); influenza B virus (B/Phuket/3073/13); adenovirus type 5 and 6; or respiratory syncytial virus (strain A2). Influenza B virus had the ability to most rapidly induce IFNs and ISGs as well as to stimulate excessive IFN-α, IFN-β and IFN-λ secretion. It seems curious that IAV H1N1pdm did not induce IFN-λ secretion, but enhanced type I IFN and interleukin (IL)-6 production. We emphasized the importance of the negative regulation of virus-triggered signaling and cellular IFN response. We showed a decrease in IFNLR1 mRNA in the case of IBV infection. The attenuation of SOCS-1 expression in IAV H1N1pdm can be considered as the inability of the system to restore the immune status. Presumably, the lack of negative feedback loop regulation of proinflammatory immune response may be a factor contributing to the particular pathogenicity of several strains of influenza. |
||
| Keywords: lambda interferons; MxA; influenza; respiratory syncytial virus; A549 cells | ||
| Published online: 22-Mar-2023 | ||
| Year: 2023, Volume: 67, Issue: 1 | Page From: 99, Page To: 108 | |
| doi:10.4149/av_2023_110 |
||
|
|
 download file |
|