Home General Physiology and Biophysics 2023 General Physiology and Biophysics Vol.42, No.4, p. 323–338, 2023

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.42, No.4, p. 323–338, 2023

Title: Biomedical research brings mTBI biomarkers a step closer to the bedside – implementation in clinical practice
Author: Martina Martinikova, Robert Ruzinak, Egon Kurca, Michael T. Grey, Stefan Sivak
Abstract: Research in the field of TBI (traumatic brain injury) has long been focused on severe brain injury, while the number of mild injuries far overweigh severe injuries. Mild head injuries constitute up to 95% of all traumatic head injuries. The purpose of this work is to identify mTBI (mild traumatic brain injury) patients who are unlikely to benefit from CT (computed tomography) scanning. Biomarkers capable of clearly discriminating between CT-positive and CT-negative subjects are needed. Biomarkers hold the potential to document whether a concussion occurred, especially when the history is unclear and neurocognitive sequelae persist. Recently, following advances in proteomics analysis, investigators have introduced ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) as two promising brain injury biomarkers. The authors provide an update on the current knowledge of TBI biomarkers, especially protein biomarkers for neuronal cell body injury (UCH-L1) and astroglial injury (GFAP, S100B), and a focused literature review dealing with implementation of mTBI biomarkers in clinical practice.
Keywords: Mild traumatic brain injury — mTBI biomarkers — GFAP — UCH-L1 — S100B
Published online: 03-Jul-2023
Year: 2023, Volume: 42, Issue: 4 Page From: 323, Page To: 338
doi:10.4149/gpb_2023013


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