Home Bratislava Medical Journal 2023 Bratislava Medical Journal Vol.124, No.9, p.707–717, 2023

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

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Bratislava Medical Journal Vol.124, No.9, p.707–717, 2023

Title: Molecular mechanisms of antidiabetic effect of betulinic acid in lotus rhizome
Author: Damean De SILVA, Upul SENARATH, Pathirage Kamal PERERA
Abstract: OBJECTIVES: To explain the bio-physiological mechanisms of the antidiabetic effect of betulinic acid in Lotus rhizome.
BACKGROUND: Even though Sri Lankan native medicine uses Lotus rhizome as a medicinal food for diabetes mellitus, its antidiabetic property has not been scientifically explained yet. It is found to compose several medicinally active components with antidiabetic properties, including Betulinic acid.
METHODS: A narrator review was conducted with a literature search in PubMed and Google Scholar databases using the search terms “Nelumbo nucifera rhizome”, “Lotus rhizome”, “phytochemicals”, “antidiabetic effect”, “hypoglycaemic effect” “Betulinic acid”, and “molecular mechanism”.
RESULTS: The triterpenoid, Betulinic acid exerts its antidiabetic effect via seven bio-physiological mechanisms including, inhibiting α-glucosidase and α-amylase, upregulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1 α, enhancing AS160 protein phosphorylation, stimulating adenosine monophosphate-activated protein kinase activation, stimulating Glucose transporter type 4 synthesis and translocation, inhibiting Protein Tyrosine Phosphatase 1 B activity preventing dephosphorylation of insulin receptor and stimulating Takeda-G-protein-receptor-5 resulting in an increased release of insulin from insulin-containing granules
CONCLUSION: The available scientific knowledge explains that betulinic acid in Lotus rhizome can improve glucose homeostasis contributing to the antidiabetic effect of this root (Tab. 1, Fig. 6, Ref. 29).
Keywords: glucose homeostasis, hypoglycemic effect, bioactive compounds, phytochemical, medicinal food, functional food
Published online: 04-Jul-2023
Year: 2023, Volume: 124, Issue: 9 Page From: 707, Page To: 717
doi:10.4149/BLL_2023_108


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